Tracking genome evolution in single cell clones reveals the rates and features of copy number alterations generated by ongoing chromosomal instability in cancer

Guscott et al., bioRxiv, 2023

Barts Cancer Institute, Queen Mary University of London
(+ERIBA Groningen)

 

Single cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers

Kabeer, Tran, Andronescu et al., bioRxiv, 2023

BCCRC (British Columbia Cancer Research Centre)
UBC (University of British Columbia)
MSKCC (Memorial Sloan Kettering Cancer Center)

 

Single-cell genomic variation induced by mutational processes in cancer

Funnell et al., Nature, 2022

Weill Cornell Medicine, MSKCC (Memorial Sloan Kettering Cancer Center), BCCRC (British Columbia Cancer Research Centre), UBC (University of British Columbia)

 

Construction of Strand-seq libraries in open nanoliter arrays

Hanlon et al., Cell Reports Method, 2022

BCCRC (British Columbia Cancer Research Centre), UBC (University of British Columbia), UMC Groningen

 

Clonal fitness inferred from time-series modelling of single-cell cancer genomes

Salehi et al., Nature, 2021

BCCRC (British Columbia Cancer Research Centre), Department of Molecular Oncology, UBC (University of British Columbia)

 

Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

Acar, Nichol et al., Nature Communications, 2020

BCCRC (British Columbia Cancer Research Centre), Department of Molecular Oncology

 

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

Laks et al., Cell, 2019

BCCRC (British Columbia Cancer Research Centre), Department of Molecular Oncology

 

Human fallopian tube organoid models of high grade serous ovarian cancer initiation

Evan William Gibbard., 2021

UBC (University of British Columbia), UMC Groningen

 

Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs

Pfisterer et al.,Genes, Chromosomes & Cancer, 2021

Center for Translational Genomics, Lund University

 

Epiclomal: Probabilistic clustering of sparse single-cell DNA methylation data

De Souza, Andronescu et al., PLOS Computational Biology, 2020

University of Western Ontario, BCCRC (British Columbia Cancer Research Centre), UBC (University of British Columbia)

 

clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers

Campbell et al., Genome Biology, 2019

BCCRC (British Columbia Cancer Research Centre), UBC (University of British Columbia), Memorial Sloan Kettering Cancer Center