Complex In-Vitro 3D models have gained significant interest in many research areas such as regenerative medicine, drug discovery, toxicity testing and cancer research. Due to their inherent clinical relevance, such 3D models like spheroids and organoids are becoming increasingly important but solutions to manipulate and isolate them aren’t widely available yet. To yield reproducible assays, the ability to pre-select spheroids based on their size, morphology and internal organization is critical. Cellenion has developed spheroONE, an innovative platform to automate sorting and dispensing of large particles.