sciDROP PICO

Q: Technical Information Piezo Dispense Capillary (PDC)

Piezo dispensingNon-contactCapillary orifice35 – 75 µmSpot frequency200 – 1500 HzTypical spot size80 – 250 µmAverage CV of drop volumes<2%, typically < 0.5 %Typical pitch (spacing)Freely scalable (> 50 µm)Capillary materialsBorosilicate glass, TEFLON® tube, PEEK fittingMaterials (in contact with medium)PEEK, stainless steel, corundumViscosity of spotable media0.4 – 5 (mPa.s)

SCIENION’s non-contact proprietary dispensing technology takes microarray spotting to the next level

10 pL to 800 pL per drop

The technology, as patented by SCIENION, is called sciDROP PICO, and covers dispensing a liquid sample from 10 pL* to 800 pL per drop.

In combination with sciDROP NANO, the total volume range between 10 pL and 100 μL is covered by a single sciFLEXARRAYER instrument.

*results obtained with optimized samples and configuration.

Non-contact technology offers a number of benefits over contact spotting

Homogenous spot morphology
No damage to sensitive surfaces, as can result from contacting metal pins
Dispensing into very small cavities
Drop volume is fully controlled by implementing a proprietary vision-based algorithm

Piezo Dispense Capillaries

SCIENION’s sciDROP PICO is a state of the art non-contact dispensing technology based on piezo driven pulses on an inert glass capillary.

This enables accurate and precise droplet deposition under various conditions.

All Piezo Dispense Capillaries (PDCs) aspirate and dispense liquid at the picoliter scale. We will determine the best PDC size and coating combination for your specific application.

Benefits of sciDROP PICO

Gentle acoustic dispensing of samples, no shear stress
Living cells are successfully dispensed
No added glycerol is needed in the system liquid
Precise drop volume control with unique visual detection
Absolute zero dead volume
No crystallization of sample inside the tip due to a round orifice
No satellite drops due to full drop ejection parameters control

Wide Range of Liquids

The sciDROP PICO option, together with SCIENION´s surface coating technology, provides access to a broad field of applications with high accuracy and precision dispensing a wide range of liquids:

Biomolecules using water based printing buffers

Small molecules using a range of organic solvents

A large number of other various viscous liquids

Dispensable Media

Thanks to our surface characterization expertise, we have developed inert glass Piezo Dispense Capillaries (PDCs) which can be coated to improve the quality of the dispensed solution. We have worked very successfully with the following solutions but this list is not exhaustive.

Technical Information Piezo Dispense Capillary (PDC)

Piezo dispensing	Non-contact
Capillary orifice	35 – 75 µm
Spot frequency	200 – 1500 Hz
Typical spot size	80 – 250 µm
Average CV of drop volumes	<2%, typically < 0.5 %
Typical pitch (spacing)	Freely scalable (> 50 µm)
Capillary materials	Borosilicate glass, TEFLON® tube, PEEK fitting
Materials (in contact with medium)	PEEK, stainless steel, corundum
Viscosity of spotable media	0.4 – 5 (mPa.s)

Piezo Dispense Capillary Sizes & Coatings

PDC 60	220-300 pl
PDC 70	300-360 pl
PDC 80	360-440 pl
PDC 90	440-520 pl
PDC 100	520-600 pl
PDC 110	600-800 pl
	With coating types
Type 1	Aqueous solutions and organic solvents
Type 2	Samples containing organic solvents like DMSO, DMF etc. and protein mixtures (lysates, allergens etc.)
Type 3	Samples containing protein solutions and organic solvents like methanol, isopropanol, acetonitrile etc.)
Type 4	Protein solutions and Sol-Gel samples
Coating special	According to customer specifications

Contact us to discuss which PDC type is optimal for your application

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