Single Cell Omics
Unlocking genomics, transcriptomics, epigenomics, and proteomics with precision miniaturization.
Single cell omics applications have revolutionized biomedical research by enabling scientists to explore cellular diversity at unprecedented depth, reshaping our understanding of genomics, transcriptomics, and epigenomics. Researchers use these approaches to unravel disease mechanisms, track developmental trajectories, and uncover the origins of complex conditions like cancer, immune disorders, and neurodegenerative diseases. By isolating and profiling individual cells, these methods reveal critical patterns in gene expression, genetic mutations, and epigenetic regulation that are often obscured in bulk analyses.
Despite their transformative potential, single cell omics workflows present several challenges. Sample preparation and cell isolation must be meticulously controlled to prevent doublets, debris, and sample loss, while downstream library preparation and sequencing demand high sensitivity and reproducibility for meaningful results. Key complexities include ensuring cell viability, data accuracy, and managing large datasets that require robust computational analysis and careful experimental design. High-throughput projects must balance the need for scale with the imperative of precision, as erroneous data can compromise insights into cellular heterogeneity and gene regulation.
The cellenONE® platforms, by integrating advanced single cell dispensing and precision liquid dispensing capabilities, help overcome these limitations, promoting reliable single cell genomics, transcriptomics, and epigenomics research for diverse biological and clinical applications.
You're in good company
These leading institutions use our single cell and 3D cell model technologies:
single cell omics applications
Single Cell Genomics (scWGS)
Discover genetic variation at the cellular level. High-precision isolation and miniaturized workflows ensure accuracy, scalability, and robust data quality.
Single Cell Transcriptomics
(sc-RNA-seq)
Reveal dynamic gene expression profiles across thousands of cells with reproducibility and minimal bias.
Image-guided isolation and gentle dispensing maximize RNA integrity, while precise volume control supports high-throughput, cost-effective single cell RNA-seq. Understand developmental trajectories, immune landscapes, and disease mechanisms at unprecedented depth and clarity.
Single Cell Multi-Omics
Profile multiple molecular layers from the same cell, integrating genomics, transcriptomics, epigenomics, or proteomics.
cellenONE enables highly flexible, customizable workflows for simultaneous measurements, reducing sample loss and cost while unlocking a holistic view of cellular states and mechanisms.
From Isolation to Insight: Empowering Single Cell Omics
cellenONE® platforms combine ultra-precise single cell dispensing with miniaturized reagent handling to streamline every stage of single cell omics workflows. Whether for genomics, transcriptomics, or multi-omics, our flexible and open technology reduces sample loss, increases reproducibility, and ensures your data quality keeps pace with your discovery goals.
Typical Single cell omics workflow
Featured resources
PUBLICATION
Nature Genetics – Early Mutational Events in Healthy Breast Cells (BCCRC / BC Cancer)
From researchers at BC Cancer (BCCRC), this paper reveals cancer-like copy number alterations in healthy breast luminal cells, offering clues to early oncogenesis. The work highlights how high-resolution single-cell profiling can detect rare events in ostensibly normal tissues, a capability strengthened by refined isolation platforms.
Publication
Nature Communications – Advancing Large-Scale Single-Cell Multi-Omics
Researchers at Pacific Northwest National Laboratory (PNNL) demonstrate how improved single-cell multi-omics workflows can scale across diverse cancer types while maintaining sensitivity, analyzing proteomics and transcriptomes of the very same single cells. This methodological study shows how advanced isolation and preparation technologies underpin reliable, high-throughput exploration of tumor heterogeneity.
BLOG
Designing for Discovery: The Technical Foundations of Single Cell Omics
This guide covers the essential principles behind reliable single-cell omics—miniaturization, cell isolation, contamination control—and shows how platforms like cellenONE support high-fidelity workflows from isolation to library prep.
